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A double-blind randomized controlled trial testing an antioxidant combination treatment (vitamin E, vitamin C, and -lipoic acid) in Alzheimers disease patients reported that this treatment was associated with accelerated cognitive decline as measured by the MMSE, despite a decrease in the level of oxidative stress (F2-isoprostane) in the cerebral spinal fluid (CSF) (19)

Biochim Biophys Acta 1760:7077

Boca Raton, FL, USA: 2014

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Therefore, the use of curcumin and cisplatin in combination for breast cancer treatment may have profound clinical implications, but further studies are still needed to ensure the effectiveness of this combination therapy in different breast cancer models and clinical treatments